Humboldt Redwoods State Park is located in northern California along Highway 101. State Route 254, the Avenue of the Giants, is a scenic alternate to Highway 101. The Avenue of the Giants runs roughly parallel to Highway 101 and through the park for approximately 32 miles. All Highway 101 exits for Humboldt Redwoods State Park, with the exception of the Salmon Creek exit, allow easy access to the Avenue of the Giants and Humboldt Redwoods State Park.

From the South:
Humboldt Redwoods State Park Headquarters and Visitor Center are approximately 228 miles north of San Francisco and 20 miles north of Garberville. Take Highway 101 north. There are several exits for the park off of Highway 101, beginning with the Avenue of the Giants/Phillipsville Exit #645.

From the North:
Humboldt Redwoods State Park Headquarters and Visitor Center are approximately 45 miles south of Eureka. Take Highway 101 south. There are several exits for the park off of Highway 101, beginning with the Avenue of the Giants/Pepperwood Exit #674.